The life-changing science behind Prolon

At Prolon, science isn’t a tagline; it’s our DNA. Developed in collaboration with the Longevity Institute at USC and created by world-renowned longevity scientist Dr. Valter Longo, Prolon’s Fasting Mimicking Diet (FMD) has been validated through 25 years of research and 40+ clinical trials. 

Supported by $48M in funding and validated by research with 18 leading institutions—including Stanford, Mayo Clinic, the University of Miami, and the University of Genoa—Prolon is the first and only patented nutrition program shown to support longevity through cellular renewal.

Founded by scientists and grounded in peer-reviewed evidence, Prolon brings biotech-grade rigor to everyday nutrition. It’s not a trend. It’s a proven intervention designed to help you live healthier, longer.

From the pioneers in longevity science

Prolon is the only nutrition program patented for supporting longevity, healthspan, and protecting lean body mass through cellular rejuvenation.

25+

Years of scientific research
Decades of studies on longevity and nutrition

47

Clinical
trials
Conducted with world-leading institutions

18

Leading research institutions
Including USC, Stanford, Mayo Clinic, and more

200+

Pending or issued patents
For optimizing longevity and healthspan
DISCOVER THE SCIENCE

Explore the research

With more than 40 clinical trials published in leading scientific and medical journals worldwide, Prolon’s impact is proven by some of the most rigorous nutrition research to date. Browse a selection of our studies below.

The FMD is the only nutrition program supported by preliminary data confirming autophagy activation in humans

A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy

Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease: controlled trial

Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial

Fasting Mimicking Diet Cycles vs a Mediterranean Diet and Cardiometabolic Risk in Overweight and Obese Hypertensive Subjects: A Randomized Clinical Trial

Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality

An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study

Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis

Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan

Fasting and cancer treatment in humans: A case series report

Fasting-mimicking diet and hormone therapy induce breast cancer regression

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms

Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control.

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