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L-Biome (Intestinal Health)

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L-Biome was developed by scientists at the Longevity Institute at the University of Southern California in collaboration with doctors at L-Nutra.

It is designed for the post 5-day ProLon fasting microbiome, from a combination of prebiotics, probiotics and DHA, all in a single daily capsule, thanks to advanced technology.

L-Biome is a supplement of Bifidobacterium Breve B3, Lactobacillus Rhamnosus HN001, Inulin and DHA.

  •  Rich in live friendly bacteria
  •  Supports healthy fasting microbiome programme
  •  Functional prebiotics
  •  Supports short-chain fatty acid production
  •  Promotes healthy gut barrier integrity
  • +Supports digestive health

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Intestinal health is essential for a healthy life. L-Biome accompanies you on your journey star

L-BIOME for optimal intestinal health

The probiotic strains Bifidobacterium Breve B3 and Lactobacillus Rhamnosus HN001 showed beneficial effects on improving life expectancy and alleviating age-related disorders by regulating the composition of the intestinal microbiota.

Bifidobacterium breve B-3

Clinical tests have shown that taking B. breve B-3 reduced the fat mass of adult subjects with a tendency to obesity. A possible improvement in the systemic inflammatory response was observed with the administration of B. breve B-3.

Lactobacillus Rhamnosus Hn001

This probiotic is particularly resistant to the action of bile. Thanks to this functionality, it is able to colonize the upper part of the small intestine and the colon. Numerous studies show that L.rhamnosus HN001 has a beneficial impact on intestinal barrier function.


It is an insoluble fiber. Although processed foods provide taste and energy, they are deficient in fiber and their long-term consumption can lead to various disorders. Several studies show that inulin acts as a prebiotic and can promote the growth of Bifidobacteria and Lactobacillus species in the intestinal tract, thereby promoting a healthy digestive system.


is an essential omega-3 polyunsaturated fatty acid, which is part of the composition of phospholipids in various organs, including the heart, brain and retina. DHA intake contributes to the maintenance of physiological brain function and normal visual capacity. Studies show that European populations consume few foods containing DHA, which creates deficiency situations that can be remedied by supplementation.


It is an essential amino acid for humans, which must therefore be supplied through food. Lysine plays several roles in humans, mainly in proteinogenesis, but also in the cross-linking of collagen polypeptides.


Innovation meets nature.


Innovation meets nature.

Selected references

Bifidumbacterium breve B-3:

  • Minami, J.I., Kondo, S., Yanagisawa, N., et al., 2015. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of Nutritional Science, 4.
  • Minami, J., Iwabuchi, N., Tanaka, M., et al., 2018. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Bioscience of Microbiota, Food and Health, pp.18-001.
  • Inoue T, Kobayashi Y, Mori N, Sakagawa M, et al., 2018. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018 Dec 7;9.

 Lactobacillus rhamnosus HN001:

  • González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF (2012) Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial. Nutr J 11:90.
  • Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. (2018) The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability inpregnancy: a randomised clinical trial. Beneficial Microbes 9(2): 199-208
  • Kruger MC, Fear A, Chua WH, Plimmer GG, Schollum LM (2009) The effect of Lactobacillus rhamnosus on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Science & Technology 89:219-231.
  • Tannock GW, Taylor C, Lawley B, Loach D, Gould M, Dunn AC, McLellan AD, Black MA, McNoe L, Dekker J, Gopal P, Collett MA (2014) Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied and Environmental Microbiology 80:2851-2859
  • Miller LE, Ouwehand AC (2013) Probiotic supplementation decreases intestinal transit time: Meta- HN019, analysis of randomized controlled trials. World Journal of Gastroenterology 19:4718-4725


  • Shah BR, Li B, Al Sabbah H, Xu W, Mráz J. Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations. Trends Food Sci Technol. 2020 Aug;102:178-192.
  • den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325–2340.
  • Dewulf E., Cani P., Claus S., Neyrinck A., Puylaert P., Glenn G.…Delzenne N. INULIN-TYPE fructans with prebiotic properties lessen endotoxemia and modulate host metabolism by changing gut microbiota composition in obese women: 749 accepted poster. Obesity Facts. 2012;5:200–201.
  • Dewulf E.M., Cani P.D., Neyrinck A.M., Possemiers S., Van Holle A., Muccioli G.G.…Sohet F.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 2011;22(8):712–722.
  • Nicolucci A.C. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711–722

Algal Oil DHA:

  • Jayapala H, Lim SY. N-3 Polyunsaturated Fatty Acids and Gut Microbiota. Comb Chem High Throughput Screen. 2022 Jul 1. doi:
  • Rousseau G. Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases. Mar Drugs. 2021 Jan 23;19(2):54.
  • Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids. 2003;126(1):1-27.
  • Serhan CN. Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology. Nature. 2014 Jun 5; 510(7503): 92–101.
  • Kotani S, Sakaguchi E, Warashina S, et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 2006;56(2):159-64.
  • Innes JK, Calder PC. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020. Int J Mol Sci. 2020 Feb 18;21(4):1362.
  • SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24(1):87-138