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L-Biome & L-Pill (intestinal health and anti-aging antioxidant)

Product information

£100.00

The fasting mimicking diet approach induces a mode of anti-aging protection in cells. FMD cycles increase regeneration markers, reduce oxidative stress and inflammation, and select for the expansion of Lactobacillaceae and Bifidobacteriaceae.

L-Biome and L-Pill are the result of the work of scientists at the Longevity Institute at the University of Southern California, in collaboration with L-Nutra doctors.

L-Biome is the best-studied model for a longevity microbiome. The synergy of Bifidobacterium Breve B3, Lactobacillus Rhamnosus HN001, Inulin and DHA support a healthy and anti-aging microbiome.

L-Pill is the best combination of natural extracts, rich in molecules well known for their antioxidant properties and in DHA, to maintain the normal antioxidant and anti-inflammatory status achieved with FMD.

  • 100% Vegan
  • Promotes healthy digestion
  • Immune health
  • Immediate energy
  • Cardiovascular health
  • Rich in pre and probiotics
  • Promotes a healthy intestinal barrier
  • Healthy fasting microbiome
  • Brain health
  • Cellular protection and healthy aging

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or pay in 3 easy installments with
Rich in Pre- and Probiotics
Helps digestion
Stimulates intestinal flora
Promotes healthy ageing
Increases cell protection
Boosts the immune system
Intestinal health is essential for a healthy life. L-Biome accompanies you on your journey star
star The L-Pill is the only supplement that I would take - Dr. Valter Longo star

WHY L-BIOME & L-PILL

Innovation meets nature.

HOW IT WORKS

How and when to use it

Selected references

Bifidumbacterium breve B-3:

  • Minami, J.I., Kondo, S., Yanagisawa, N., et al., 2015. Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of Nutritional Science, 4.
  • Minami, J., Iwabuchi, N., Tanaka, M., et al., 2018. Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Bioscience of Microbiota, Food and Health, pp.18-001.
  • Inoue T, Kobayashi Y, Mori N, Sakagawa M, et al., 2018. Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. Benef Microbes. 2018 Dec 7;9.

 Lactobacillus rhamnosus HN001:

  • González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF (2012) Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: a double-blind randomized controlled pilot trial. Nutr J 11:90.
  • Mokkala K, Pussinen P, Houttu N, Koivuniemi E, Vahlberg T, Laitinen K. (2018) The impact of probiotics and n-3 long-chain polyunsaturated fatty acids on intestinal permeability inpregnancy: a randomised clinical trial. Beneficial Microbes 9(2): 199-208
  • Kruger MC, Fear A, Chua WH, Plimmer GG, Schollum LM (2009) The effect of Lactobacillus rhamnosus on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Science & Technology 89:219-231.
  • Tannock GW, Taylor C, Lawley B, Loach D, Gould M, Dunn AC, McLellan AD, Black MA, McNoe L, Dekker J, Gopal P, Collett MA (2014) Altered transcription of murine genes induced in the small bowel by administration of probiotic strain Lactobacillus rhamnosus HN001. Applied and Environmental Microbiology 80:2851-2859
  • Miller LE, Ouwehand AC (2013) Probiotic supplementation decreases intestinal transit time: Meta- HN019, analysis of randomized controlled trials. World Journal of Gastroenterology 19:4718-4725

Inulin:

  • Shah BR, Li B, Al Sabbah H, Xu W, Mráz J. Effects of prebiotic dietary fibers and probiotics on human health: With special focus on recent advancement in their encapsulated formulations. Trends Food Sci Technol. 2020 Aug;102:178-192.
  • den Besten G., van Eunen K., Groen A.K., Venema K., Reijngoud D.-J., Bakker B.M. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research. 2013;54(9):2325–2340.
  • Dewulf E., Cani P., Claus S., Neyrinck A., Puylaert P., Glenn G.…Delzenne N. INULIN-TYPE fructans with prebiotic properties lessen endotoxemia and modulate host metabolism by changing gut microbiota composition in obese women: 749 accepted poster. Obesity Facts. 2012;5:200–201.
  • Dewulf E.M., Cani P.D., Neyrinck A.M., Possemiers S., Van Holle A., Muccioli G.G.…Sohet F.M. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. The Journal of Nutritional Biochemistry. 2011;22(8):712–722.
  • Nicolucci A.C. Prebiotics reduce body fat and alter intestinal microbiota in children who are overweight or with obesity. Gastroenterology. 2017;153(3):711–722

Algal Oil DHA

  • Jayapala H, Lim SY. N-3 Polyunsaturated Fatty Acids and Gut Microbiota. Comb Chem High Throughput Screen. 2022 Jul 1. doi: https://pubmed.ncbi.nlm.nih.gov/35786331/
  • Rousseau G. Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases. Mar Drugs. 2021 Jan 23;19(2):54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931107/
  • Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids. 2003;126(1):1-27.
  • Serhan CN. Novel Pro-Resolving Lipid Mediators in Inflammation Are Leads for Resolution Physiology. Nature. 2014 Jun 5; 510(7503): 92–101.
  • Kotani S, Sakaguchi E, Warashina S, et al. Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. Neurosci Res 2006;56(2):159-64.
  • Innes JK, Calder PC. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020. Int J Mol Sci. 2020 Feb 18;21(4):1362.
  • SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24(1):87-138

Wasabi Japonica

  • 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) from Wasabia japonica alleviates inftammatory bowel disease (IBD) by potential inhibition of glycogen synthase kinase 3 beta (GSK-3b)_European Journal of Medicinal Chemistry _2021.
    • Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice_Nutrients_2021
    • Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica_eCAM_2010_IF2.6. 9
    • Anticancer and Anti-Neuroinftammatory Constituents Isolated from the Roots of Wasabia japonica_an- tioxidants_2022
    • Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori_International Journal of Food Microbiology_2004
    • Inhibitory effects of Japanese horseradish (Wasabia japonica) on the formation and genotoxicity of a potent carcinogen, acrylamide_J Sci Food Agric_2017
    • Wasabi leaf extracts attenuate adipocyte hypertrophy through PPARγ and AMPK_Bioscience, Biotechnolo- gy, and Biochemistry_2016
    • Molecular Mechanisms Underlying Anti-Inftammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica )_Advances in Pharmacological Sciences_2012
    • Neuroprotective and Anti-Inftammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κ
    • Anti-angiogenic effects of dietary isothiocyanates/ Mechanisms of action and implications for human health_Biochemical Pharmacology_2011
    • Anti-inftammatory potential of allyl-isothiocyanate – role of Nrf2, NF-(k)B and microRNA-155_J. Cell. Mol.

Med._2012

  • Neuroprotective and Anti-Inftammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κ B/TNF-α Signaling_Int. J. Mol. Sci_2017_

Flavonoids and polyphenols from cane sugar extract

  • Antithrombotic activity of ftavonoids and polyphenols rich plant speciesMIRZA BOJIĆ ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, HR-10000 Zagreb, Croatia
    • Raúl Arcusa, Juan Ángel Carillo, Begoña Cerdá, Thierry Durand, Ángel Gil-Izquierdo, Sonia Medina, Jean-Marie Galano, María Pilar Zafrilla, Javier Marhuenda, Ability of a Polyphenol-Rich Nutraceutical to Reduce Central Nervous System Lipid Peroxidation by Analysis of Oxylipins in Urine: A Randomized, Double-Blind, Place- bo-Controlled Clinical Trial, Antioxidants, 10.3390/antiox12030721, 12, 3, (721), (2023).
    • Michael Aviram, Bianca Fuhrman,Polyph enolic ftavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis,Atherosclerosis
    • Postprandial insulin and glucose levels are reduced in healthy subjects when a standardised breakfast meal is supplemented with a filtered sugarcane molasses concentrate_EurJnutr_2015
    • Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract_JAmerCollofNutr_2019_
    • A polyphenol rich sugarcane extract as a modulator for inftammation and T neurological disorders_Phar- maNutr_2020
    • Immunomodulatory Properties of Polyphenol-Rich Sugarcane Extract on Human Monocytes_Biologic- s_2021
    • Age-Deterring and Skin Care Function of a Polyphenol Rich Sugarcane Concentrate_Cosmetics_2020
    • Antioxidant activity and polyphenol composition of sugarcane molasses extract_JFoodChem_2020_
    • Phytochemical profile of sugarcane and its potential health aspects_PhcogRev_2015_I

Catechins and caffeine from green tea extract

  • Luis Goya, Ricardo San Román, Sonia de Pascual-Teresa, Polyphenols’ Effect on Cerebrovascular Health, Current Medicinal Chemistry, 10.2174/0929867328666211129123459, 29, 6, (1029-1044), (2022).
    • Sally C. Duplantier, Christopher D. Gardner, A Critical Review of the Study of Neuroprotective Diets to Reduce Cognitive Decline, Nutrients, 10.3390/nu13072264, 13, 7, (2264), (2021).
    • Bradley J. McEwen, Impact of cardiometabolic disease on cognitive function, Nutraceuticals in Brain Health and Beyond, 10.1016/B978-0-12-820593-8.00025-2, (357-368), (2021).
  • Chacko SM, Thambi PT, Kuttan R, Nishigaki I. Beneficial effects of green tea: a literature review. Chin Med. 2010 Apr 6;5:13. doi: 10.1186/1749-8546-5-13. PMID: 20370896; PMCID: PMC2855614.
    • Prasanth MI, Sivamaruthi BS, Chaiyasut C,Tencomnao T. A Review of the Role of Green Tea (Camellia sinen- sis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy. Nutrients. 2019 Feb 23;11(2):474. doi: 10.3390/nu11020474. PMID: 30813433; PMCID: PMC6412948.
    • Mengyuan Si, Zhongyuan Liu, Yingchao Dou, Guanyu Yang, Synthesis of Catechol Thioethers through Gallic Acid/Fe2(SO4)3 Catalyzed Aerobic Oxidative Coupling of Thiols and Catechol Derivatives, ChemistrySelect, 10.1002/slct.202103752, 6, 48, (13781-13785), (2021).